Toranomon Hospital Endocrine Center, 2-2-2 Toranomon, Minato-Ku, Tokyo, 105-8470, Japan. takeuchi-tky@umin.ac.jp. Okinaka Memorial Institute for Medical Research, 2-2-2 Toranomon, Minato-Ku, Tokyo, 105-8470, Japan. takeuchi-tky@umin.ac.jp. Medical Affairs Department Asahi Kasei Pharma Corporation, 1-105 Kanda Jinbocho, Chiyoda-Ku, Tokyo, 101-8101, Japan. Internal Medicine 1, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan. Research Institute and Practice for Involutional Diseases, 1610-1 Meisei, Misato, Azumino, Nagano, 399-8101, Japan. National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-Ku, Tokyo, 162-8655, Japan.